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KMID : 0363220100480090786
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Korean Journal of Dermatology
2010 Volume.48 No. 9 p.786 ~ p.789
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Embolia Cutis Medicamentosa Following Intramuscular Injection of Diclofenac
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Go Jae-Wan
Kim Shin-Han
Ro Byung-In
Oh Hwa-Eun
Cho Han-Kyoung
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Abstract
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Nicolau syndrome or embolia cutis medicamentosa is a rare complication of a still largely unidentified pathogenesis at the site of intramuscular injections of various drugs. It is characterized by development of an acute, severe pain around the injection site followed by a localized erythema, a reticular rash, a hemorrhagic patch and varying degrees of tissue damage. The disease outcomes vary from atrophic ulcers and pigmentation to lower limb paralysis and limb amputation. We describe a 34-year-old woman with the diagnosis of this syndrome after she received an intramuscular diclofenac-beta-dimethyl-aminoethanol injection to the lateral aspect of the right upper buttock. The patient was treated by surgical debridement with concomitant primary closure.
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KEYWORD
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Diclofenac, Nicolau syndrome
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